Correlation of Preoperative HE-4 and CA125 with Ovarian Cancer Staging in Ahvaz Imam Khomeni Hospital

  Background: Given that ovarian cancer symptoms are nonspecific and that appropriate surgical staging and pathological grading are important for the best treatment and prognosis of patients, this study aimed to determine the correlation of preoperative serum levels of CA125 and He4 with staging and grading. Materials and Methods: This cross-sectional study recruited 29 patients with epithelial ovarian cancer who underwent staging based on FIGO protocol and grading by pathologist during 2011-13. Serum CA125 and He4 were determined preoperatively to measure the correlation of these tumor markers with staging and grading. Results: We did not observe a significant correlation between preoperative serum levels of CA125 and He4, and ovarian epithelial cancer staging and grading (P>0.05). However, serum levels of CA125 and He4 were significantly correlated with each other (P>0.001). Conclusion: Based on this study, we cannot differentiate epithelial ovarian cancer surgical staging or pathological grading by preoperative CA125 and He4 serum levels.